Markovnikov'S Rule
Chemical Reactions & Kinetics - Related Topics
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Basic Concepts Of Chemistry
1Chemistry is often referred to as the "central science" because it plays a fundamental and unifying role in the natural sciences. It serves as a bridge between physics and biology.
Basics Of Environment
2Environment refers to the surroundings or conditions in which a person, animal, or plant lives or operates. It encompasses both natural and human-m...
Chemistry Acetaldehyde
4Acetaldehyde is a colorless, flammable liquid with a pungent, fruity odor. It is the simplest aldehyde, and is an important intermediate in the pro...
Chemistry Acetylsalicylic Acid
1031Acetylsalicylic acid, also known as aspirin, is a widely used medication that has been used for over a century for its pain-relieving, anti-inflamm...
Chemistry Acid And Base Difference
1032Acids and bases are two fundamental concepts in chemistry. They play a vital role in various chemical reactions and processes. Understanding the pr...
Chemistry Acid Chloride
1033An acid chloride is a functional group in organic chemistry with the general formula RCOCl. It consists of a carbonyl group (C=O) bonded to a chlor...
Chemistry Glycerin
1034Glycerin, also known as glycerol, is a simple polyol compound. It is a viscous, colorless, odorless, and sweet-tasting liquid that is widely used i...
Chemistry Grignard Reaction Mechanism
1035A Grignard reagent, also known as an organomagnesium halide, is a chemical compound with the general formula RMgX, where R is an organic group and ...
Chemistry Group 17 Elements
1037Halogens are a group of elements in the periodic table that are known for their high reactivity and toxicity. They are located in Group 17 (also kn...
Chemistry Haloform Reaction Mechanism
1038The haloform reaction is a chemical reaction in which a methyl ketone or aldehyde is converted into a haloform (a compound with the formula CHX3) and a carboxylate ion. This reaction is important in organic synthesis.
Chemistry Heck Reaction
1039The Heck reaction is a palladium-catalyzed carbon-carbon bond-forming reaction that involves the coupling of an aryl or vinyl halide with an alkene...
Chemistry Helium
1040Helium is a chemical element with the symbol He and atomic number 2. It is a colorless, odorless, non-flammable, non-toxic, inert gas that heads th...
Chemistry Hess Law
1041Hess's Law of Constant Heat Summation states that the total enthalpy change for a chemical reaction is independent of the pathway taken. In other w...
Chemistry Histidine
1042Histidine is an essential amino acid that is found in many foods, including meat, fish, poultry, dairy products, and legumes. It is also available ...
Chemistry Hoffmann Bromamide Reaction
1043The Hofmann bromamide reaction is a chemical reaction that converts a primary amide into an amine. The reaction is initiated by the addition of bro...
Chemistry Homologous Series
1044A homologous series is a group of organic compounds that have similar chemical properties and structures. The members of a homologous series differ...
Chemistry Hunds Rule
1045Hund's rule is a chemical rule that states that the lowest energy configuration for a set of electrons in an atom or molecule is the one in which t...
Chemistry Hunsdiecker Reaction
1046The Hunsdiecker reaction is a chemical reaction used to convert a carboxylic acid into an alkyl halide. It involves the reaction of a silver salt o...
Chemistry Hydroboration Oxidation Reaction
1047The hydroboration oxidation reaction is a two-step process that converts an alkene into an alcohol. The first step is the hydroboration, in which t...
Chemistry Hydroxide
1051Hydroxide is a polyatomic anion with the chemical formula OH-. It consists of one oxygen atom covalently bonded to one hydrogen atom with a negative charge. Hydroxide compounds are important in many chemical processes.
Chemistry Ideal Gas Equation
1052The ideal gas equation is a fundamental equation in thermodynamics that describes the behavior of gases under various conditions. It establishes a ...
Chemistry Interstitial Compounds
1054Interstitial compounds are a class of materials that are formed by the insertion of atoms or molecules into the interstitial sites of a crystal lat...
Chemistry Iodine
1055Iodine is a chemical element with the symbol I and atomic number 53. It is the heaviest stable halogen and is essential for life. Iodine is found i...
Chemistry Isopropyl Alcohol
1058Isopropyl alcohol, also known as rubbing alcohol or 2-propanol, is a colorless, flammable liquid with a strong odor. It is a common household produ...
Chemistry Lactic Acid
1060Lactic acid, also known as 2-hydroxypropanoic acid, is a colorless, water-soluble organic compound with the chemical formula CH3CHOHCOOH. It is naturally produced in muscles during exercise.
Chemistry Leaching
1062Complete guide to leaching including types, heap leaching, in-situ leaching, applications, factors affecting leaching for NEET chemistry
Chemistry Lewis Acid And Base
1063A Lewis acid is a substance that can accept a pair of electrons, while a Lewis base is a substance that can donate a pair of electrons. This concep...
Chemistry Lindlar Catalyst
1064The Lindlar catalyst is a heterogeneous catalyst used in organic chemistry for the selective hydrogenation of alkynes to alkenes. It is composed of...
Chemistry Liquid State Of Matter
1065Liquids are one of the three fundamental states of matter, characterized by their fluidity and ability to flow. They exhibit distinct properties th...
Chemistry Lithium
1066Lithium (Li) is the lightest metal and the least dense solid element. It is a soft, silvery-white metal that is highly reactive and flammable. Lith...
Chemistry Litmus Paper
1067Litmus paper is a type of indicator used to test the acidity or alkalinity of a solution. It is made from a special type of paper that has been tre...
Chemistry Livermorium
1068Livermorium (Lv) is a synthetic chemical element with the atomic number 116. It is a radioactive element that belongs to the group of superheavy el...
Chemistry Lutetium
1069Lutetium is a chemical element with the symbol Lu and atomic number 71. It is the last element in the lanthanide series and is therefore considered...
Chemistry Magnetic Quantum Number
1070The magnetic quantum number (ml) describes the orientation of an atomic orbital in space. It is the third of the four quantum numbers used to descr...
Chemistry Maillard Reaction
1071The Maillard reaction is a chemical reaction between amino acids and reducing sugars that occurs when food is heated. It is responsible for the bro...
Chemistry Maltose
1072Maltose, also known as malt sugar, is a disaccharide composed of two glucose molecules joined by an α(1→4) glycosidic bond. It is a white, crystall...
Chemistry Mannitol
1073Mannitol is a sugar alcohol that is found naturally in some fruits and vegetables, such as celery, mushrooms, and asparagus. It is also produced co...
Chemistry Markovnikov Rule
1074Markovnikov's rule is an empirical observation in organic chemistry that states that when an unsymmetrical alkene reacts with an electrophile, the ...
Chemistry Methanol
1076Methanol, also known as methyl alcohol, is a chemical compound with the formula CH3OH. It is a colorless, flammable liquid with a distinctive odor and various industrial applications.
Chemistry Methylene Blue
1077Methylene blue is a thiazine dye with the chemical formula C16H18ClN3S. It has a variety of uses in different fields, including medicine, biology, and chemistry.
Chemistry Milk Of Magnesia
1078Milk of Magnesia, also known as magnesium hydroxide, is a common over-the-counter medication used to treat a variety of conditions, including const...
Chemistry Molality
1079Molality (m) is a measure of concentration that expresses the amount of solute in a given mass of solvent. It is defined as the number of moles of ...
Chemistry Molar Conductance
1080Molar conductance is a measure of the ability of a solution to conduct electricity. It is defined as the conductance of a solution containing one m...
Chemistry Neutralization Reaction
1082A neutralization reaction is a chemical reaction in which an acid and a base react in stoichiometric amounts to form a salt and water. The reaction...
Chemistry Nickel Sulfate
1083Nickel sulfate is a chemical compound with the formula NiSO₄. It is the most common nickel compound and is used in electroplating, as a source of n...
Chemistry Nihonium
1084Nihonium (Nh) is a chemical element with the atomic number 113. It is a synthetic element, first synthesized in 2004 at the RIKEN Nishina Center fo...
Chemistry Ninhydrin Test
1085The ninhydrin test is a chemical test used to detect the presence of amino acids, peptides, and proteins. It is based on the reaction of these comp...
Chemistry Nitrous Oxide 2
1087Nitrous oxide, commonly known as laughing gas, is a colorless, non-flammable gas with a slightly sweet odor. It is used as an anesthetic, pain reli...
Chemistry Nuclear Reaction
1088A nuclear reaction is a process in which the nucleus of an atom changes. This can occur through a variety of processes, including:
Laws Of Chemical Combination
2051The law of conservation of mass states that mass can neither be created nor destroyed, only transformed from one form to another. This means that t...
Learn The Difference Between Molecule And Compound With Examples
2052Molecules are the basic unit of matter and the defining structure of elements and compounds. They are made up of atoms, which are the smallest unit...
Everyday Applications Of Chemistry In Chemical Explosives
4367Chemical explosives are substances that undergo a rapid chemical reaction, releasing large amounts of heat and gas. This process, known as detonati...
Everyday Applications Of Chemistry In Cleansing Action Of Soap Detergents
4368Soaps are cleaning agents that are typically used for washing and cleaning. They are made from fats and oils that have been reacted with an alkali,...
Everyday Applications Of Chemistry In Manufacturing Glass And Ceramics
4369Glass is a hard, brittle, and transparent material made from the fusion of silica and other ingredients such as soda ash and lime. It is typically ...
Everyday Applications Of Chemistry In Medical Science And Drugs
4370Drugs and medicines are substances that are used to treat, prevent, or diagnose diseases. They can be natural or synthetic, and they can be taken i...
Everyday Applications Of Chemistry In The Food And Food Industry
4371Food additives are substances added to food to improve or maintain its quality, safety, or nutritional value. They are used to preserve food, enhan...
Everyday Applications Of Chemistry In The Paints And Varnishes
4372Paints are liquids, typically applied to a surface, that dry to form a solid film. They are used to protect, color, or decorate a wide variety of s...
Chemistry Perkin Reaction Mechanism
4467The Perkin reaction is an organic reaction used to synthesize cinnamic acids and their derivatives. It involves the condensation of an aromatic ald...
Chemistry Phenol Acidity
4468Phenols are a class of organic compounds that contain a hydroxyl group (-OH) attached to a benzene ring. They are weak acids, meaning that they can donate protons in solution.
Chemistry Phenol
4469Phenols are a class of organic compounds that consist of a hydroxyl group (-OH) attached to a benzene ring. They are characterized by their distinctive properties and various industrial applications.
Chemistry Phenolphthalein
4470Phenolphthalein is a chemical compound with the formula C20H14O4. It is a weak acid that is used as an indicator in acid-base titrations. Phenolphthalein changes color from colorless to pink in basic solutions.
Chemistry Phosphoric Acid
4471Phosphoric acid is a weak inorganic acid with the chemical formula H3PO4. It is a colorless, odorless, and viscous liquid that is soluble in water and has various industrial applications.
Chemistry Plutonium
4472Plutonium is a radioactive element with the atomic number 94. It is a member of the actinide series and is the heaviest element that can be found i...
Chemistry Polyethylene Terephthalate
4474Polyethylene terephthalate (PET) is a thermoplastic polymer resin of the polyester family and is used in fibers for clothing, containers for liquid...
Chemistry Polymers
4475Polymers are large molecules composed of repeating structural units called monomers. They are the primary components of plastics, fibers, and rubbe...
Chemistry Potassium Acetate
4476Potassium acetate is a white, crystalline powder that is soluble in water. It is a potassium salt of acetic acid. Potassium acetate is used in a va...
Chemistry Potassium Hydroxide
4477Potassium hydroxide, also known as lye, is a highly caustic, white, solid inorganic compound with the formula KOH. It is a potent base that has various industrial applications.
Chemistry Potassium Nitrate
4478Potassium nitrate, also known as saltpeter, is a chemical compound with the formula KNO3. It is an ionic salt composed of potassium ions and nitrate ions with various industrial applications.
Chemistry Precipitation Reaction
4479Complete guide to precipitation reactions including types, properties, applications, double-replacement reactions for NEET chemistry
Chemistry Preparation Of Alcohols
4480Alcohols are a class of organic compounds that contain a hydroxyl (-OH) group bonded to a carbon atom. They are versatile compounds with various preparation methods and industrial applications.
Chemistry Properties Of Hydrogen
4481The periodic table is a tabular arrangement of chemical elements, organized on the basis of their atomic number, electron configurations, and recur...
Chemistry Proton
4482A proton is a subatomic particle that is a fundamental building block of matter. It is classified as a baryon, which is a type of hadron, and is fo...
Chemistry Quantum Numbers Electronic Configuration
4483Quantum numbers are a set of four numbers that describe the state of an electron in an atom. They are:
Chemistry Radioactive Elements
4484Radioactive elements are elements that have unstable atomic nuclei and emit radiation in order to achieve stability. This radiation can be in the f...
Chemistry Rate Of Reaction
4485The reaction rate is a measure of how fast a chemical reaction occurs. It is defined as the change in concentration of reactants or products over t...
Chemistry Reactivity Series
4486The reactivity series, also known as the activity series, is a list of metals arranged in order of their reactivity. The more reactive a metal is, ...
Chemistry Carbonyl Compounds
4487Carbonyl compounds are a class of organic compounds that contain a carbon-oxygen double bond (C=O). They are one of the most important functional g...
Chemistry Redox Titration
4487Complete guide to redox titration including types, principles, indicators, permanganate titration, applications for NEET chemistry
Chemistry Catalysis
4488A catalyst is a substance that increases the rate of a chemical reaction without being consumed in the reaction. Catalysts are often used in indust...
Chemistry Refining
4488Refining is the process of purifying a metal by removing impurities. It is usually done by heating the metal to a high temperature and then adding ...
Chemistry Centrifugation
4489Centrifugation is a laboratory technique that uses centrifugal force to separate particles in a solution. It is commonly used in biological and che...
Chemistry Reformatsky Reaction
4489The Reformatsky reaction is an organic reaction used to synthesize β-hydroxy esters from an aldehyde or ketone and an α-haloester in the presence o...
Chemistry Reversible And Irreversible Changes
4490Reversible changes are changes that can be undone. For example, if you melt a piece of chocolate, you can solidify it again by cooling it down.
Chemistry Chemical Equations
4491Complete guide to chemical equations including balancing, stoichiometry, conservation of mass, reaction types, writing equations for NEET chemistry
Chemistry S-Block Elements
4491S-block elements are the elements in the periodic table that belong to Group 1 (alkali metals) and Group 2 (alkaline earth metals). These elements ...
Chemistry Chemical Reaction
4492A chemical reaction is a process in which one or more substances, called reactants, are transformed into one or more different substances, called p...
Chemistry Salicylic Acid
4492Salicylic acid is a beta hydroxy acid (BHA) that is found naturally in the bark of willow trees. It is a common ingredient in skincare products, wh...
Chemistry Chlorine
4493Chlorine is a chemical element with the symbol Cl and atomic number 17. It is a halogen, and is the second lightest halogen after fluorine. Chlorin...
Chemistry Saponification
4493Saponification is the process of converting fats and oils into soap and glycerol. It is a chemical reaction that occurs when a fat or oil is heated...
Chemistry Chloroacetic Acid
4494Chloroacetic acid is a colorless, corrosive liquid with a pungent odor. It is a strong acid and can cause severe burns to the skin and eyes. Chloro...
Chemistry Schiff Bases
4494A Schiff base, also known as an imine, is a functional group that contains a carbon-nitrogen double bond with the general structure R<sub>2</sub>C=...
Chemistry Chromic Acid
4495Chromic acid, also known as chromium trioxide, is a bright red, crystalline compound with the chemical formula CrO3. It is a strong oxidizing agent with various industrial applications.
Chemistry Schotten Baumann Reaction
4495The Schotten-Baumann reaction is a classic organic reaction for the synthesis of amides from an amine and an acyl chloride. It is named after the G...
Chemistry Chromium
4496Chromium (Cr) is a transition metal in Group 6 of the periodic table with the atomic number 24. Its electronic configuration plays a crucial role i...
Chemistry Second Order Reaction
4496A second-order reaction is a chemical reaction in which the rate of the reaction is proportional to the square of the concentration of one or more ...
Chemistry Citric Acid
4497Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is a white, crystalline powder with a sour taste. Citric acid is used...
Chemistry Sedimentation
4497Sedimentation is the process by which sediment is deposited out of suspension in water or air. It is a major geological process that shapes the Ear...
Chemistry Colloids
4498Colloids are mixtures in which one substance is dispersed throughout another in the form of very fine particles. The dispersed phase is usually a s...
Chemistry Separation
4498Most of the time the substances that we see around us are not in their pure form. They are basically a mixture of two or more substances. Interesti...
Chemistry Combustion Reaction
4499A combustion reaction is a chemical reaction that involves the burning of a fuel with oxygen to produce heat and light. The fuel can be a solid, li...
Chemistry Sieving
4499Sieving is a method used to separate particles of different sizes. It is a mechanical process that involves passing a mixture of particles through ...
Chemistry Condensation
4500Condensation is the process in which water vapor in the air turns into liquid water. This happens when the air is cooled to the point where it can ...
Chemistry Corey House Reaction
4501The Corey-House reaction is an organic reaction used to synthesize alkenes from alkyl halides and carbonyl compounds. It is a two-step process that...
Chemistry Coupling Reaction
4502A coupling reaction is a chemical reaction in which two or more molecules are joined together to form a new molecule. The term "coupling" is used because the molecules are linked or coupled together.
Chemistry Slaked Lime
4502Slaked lime, also known as calcium hydroxide, is a white, powdery substance that is produced by the reaction of quicklime (calcium oxide) with wate...
Chemistry SN1 Reaction Mechanism
4503In organic chemistry, a unimolecular nucleophilic substitution reaction (SN1) is a reaction in which a nucleophile attacks an electrophile, resulti...
Chemistry Crystallization
4504Crystallization is the process by which a solid forms from a liquid or gas. It is a natural process that occurs when the temperature of a liquid or...
Chemistry SN2 Reaction Mechanism
4504A nucleophilic substitution reaction is a chemical reaction in which a nucleophile (a species that donates an electron pair) replaces a leaving gro...
Chemistry Sodium Acetate
4505Sodium acetate is a chemical compound made up of sodium (Na), oxygen (O), carbon (C), and hydrogen (H) atoms. It acts as the sodium salt of acetic ...
Chemistry D Block Elements
4506D-block elements are the elements in the periodic table that belong to Groups 3 to 12. These elements are characterized by the presence of one or m...
Chemistry Sodium Citrate
4506Sodium citrate is a white, crystalline powder that is highly soluble in water. It is a sodium salt of citric acid, which is a weak organic acid fou...
Chemistry Daltons Law Of Partial Pressure
4507Dalton's law of partial pressure states that the total pressure of a mixture of gases is equal to the sum of the partial pressures of each gas in t...
Chemistry Decantation
4508Decantation is a process of separating a liquid from a solid by pouring the liquid off, leaving the solid behind. It is a simple and effective tech...
Chemistry Decarboxylation Reaction
4509A decarboxylation reaction is a chemical reaction that removes a carboxyl group (-COOH) from an organic compound, resulting in the release of carbon dioxide. This reaction is important in many organic synthesis processes.
Chemistry Decomposition Reaction
4510Complete guide to decomposition reactions including types, thermal decomposition, photodecomposition, electrolytic decomposition, applications for NEET chemistry
Chemistry Defects In Crystal Structure
4511Crystals are highly ordered structures, but they can contain defects that disrupt the regular arrangement of atoms or molecules. These defects can ...
Chemistry Degree Of Freedom
4512The degrees of freedom of a particle are the ways in which it can move. For example, a particle in a one-dimensional space has one degree of freedo...
Chemistry Density Of Unit Cell
4513The density of a unit cell is defined as the mass of the unit cell divided by its volume. It is typically expressed in grams per cubic centimeter (...
Chemistry Destructive Distillation
4514Destructive distillation is a chemical process that involves heating a substance in the absence of air (oxygen) to produce various products. This p...
Chemistry Diazotization Reaction
4515The diazotization reaction is a chemical reaction that converts a primary aromatic amine into a diazonium salt. This reaction is typically carried ...
Chemistry Diels Alder Reaction
4516The Diels-Alder reaction is a chemical reaction between a conjugated diene and a dienophile, resulting in the formation of a cyclic compound. It is...
Chemistry Dilute Acid
4517A dilute acid is an acid that has been mixed with water. The concentration of the acid in a dilute acid solution is lower than the concentration of...
Chemistry Dipole Moment
4518An electric dipole moment is a measure of the separation of positive and negative electrical charges in a system. It is a vector quantity, and its ...
Chemistry Displacement Reaction
4519A displacement reaction is a chemical reaction in which one element replaces another element in a compound. The element that is replaced is called ...
Chemistry Distillation
4520Complete guide to distillation including types, simple distillation, fractional distillation, applications, process for NEET chemistry
Chemistry Electrode Potential
4521Electrode potential is a measure of the tendency of an electrode to undergo oxidation or reduction. It is expressed in volts (V) and is measured re...
Chemistry Sodium Hydroxide
4667Sodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula NaOH. It is a white solid ionic compound consisting of sodium cations and hydroxide anions.
Chemistry Sodium Sulfate
4668Sodium sulfate is a chemical compound with the formula Na2SO4. It is a white, crystalline solid that is highly soluble in water and has various industrial applications.
Chemistry Sodium Thiosulfate
4669Sodium thiosulfate is a chemical compound with the formula Na2S2O3. It is a white, crystalline solid that is soluble in water and has various applications in photography and medicine.
Chemistry Solutions
4670Complete guide to chemistry solutions including solute, solvent, concentration, molarity, types of solutions, and properties for NEET chemistry
Chemistry Specific Conductance
4671Specific conductance is a measure of the ability of water to conduct electricity. It is expressed in units of microsiemens per centimeter (µS/cm). ...
Chemistry Standard Electrode Potential
4672The standard electrode potential is a measure of the tendency of a chemical species to undergo oxidation or reduction. It is defined as the potenti...
Chemistry Stearic Acid
4673Stearic acid is a saturated fatty acid with the chemical formula CH3(CH2)16COOH. It is a white, waxy solid at room temperature and is insoluble in water but soluble in organic solvents.
Chemistry Sublimation
4674Sublimation is the process in which a solid directly changes into a gas without passing through the liquid phase. This process occurs when the temp...
Chemistry Substitution Reaction
4675A substitution reaction is a chemical reaction in which one functional group in a molecule is replaced by another functional group. Substitution re...
Chemistry Sulfuric Acid
4676Sulfuric acid, also known as oil of vitriol, is a highly corrosive, mineral acid. It is one of the most important industrial chemicals, with a wide...
Chemistry Suzuki Coupling Reaction
4677The Suzuki coupling reaction is a palladium-catalyzed carbon-carbon bond-forming reaction between an organoborane and an organic halide. It is a ve...
Chemistry Tannic Acid
4679Tannic acid, also known as tannin, is a type of polyphenol that is found in many plants, including grapes, tea leaves, and oak bark. It is a natura...
Chemistry Tetravalency Of Carbon
4680Carbon is a chemical element with the symbol C and atomic number 6. It is a nonmetallic element that belongs to Group 14 on the periodic table. Car...
Chemistry Types Of Solids
4683Solids are classified into various categories based on their structural and bonding characteristics. Here are some common classifications of solids:
Chemistry Ullmann Reaction
4684The Ullmann reaction is a chemical reaction used to synthesize biaryls, which are compounds containing two aromatic rings connected by a carbon-car...
Chemistry Unit Cell
4685A unit cell is the smallest repeating unit of a crystal lattice. It is a three-dimensional parallelepiped that contains all the information necessa...
Chemistry Uranium
4687Uranium is a radioactive metal that is used as a fuel in nuclear reactors. It is the heaviest naturally occurring element, and it is also the most ...
Chemistry Volumetric Analysis
4688Volumetric analysis, also known as titrimetry, is a quantitative chemical analysis method that uses the measurement of the volume of a solution of ...
Chemistry Wittig Reaction
4689The Wittig reaction is a chemical reaction used to synthesize alkenes and other carbon-carbon double bonds. It involves the reaction of a phosphoru...
Chemistry Wurtz Fittig Reaction
4690The Wurtz Fittig reaction is a chemical reaction used to synthesize symmetrical and unsymmetrical biaryls (compounds containing two aromatic rings)...
Chemistry Wurtz Reaction
4691The Wurtz reaction is a chemical reaction in which two alkyl halides are coupled to form a new alkane. The reaction is named after the French chemi...
Chemistry Zero Order Reaction
4692Complete guide to zero order reactions including rate law, kinetics, concentration, reaction mechanisms, examples for NEET chemistry
Chemistry Ziegler Natta Catalyst
4693The Ziegler Natta catalyst is a type of coordination catalyst used in the polymerization of olefins. It is named after the two chemists who develop...
Chemistry Zinc Sulfate
4694Zinc sulfate is a white, crystalline powder that is highly soluble in water. It is a source of the mineral zinc, which is essential for human healt...
Surface Chemistry
4695Surface chemistry is the study of the chemical and physical phenomena that occur at the interface of two phases, typically a solid and a gas or liq...
Surface Tension
4696Intermolecular forces are the forces that act between molecules. They are responsible for the physical properties of substances, such as their boil...
Chemistry Acid Rain
15100Acid rain is a type of precipitation that contains high levels of nitric and sulfuric acids. It is caused by the release of sulfur dioxide and nitr...
Chemistry Adsorption
15101Adsorption is the adhesion of atoms, ions, or molecules from a gas, liquid, or dissolved solid to a surface. This process creates a film of the ads...
Chemistry Alcohols And Its Types
15102Alcohols are a class of organic compounds that contain a hydroxyl (-OH) group attached to a carbon atom. They are often referred to as "drinking alcohol" and have various industrial applications.
Chemistry Aldehydes Ketones
15103The carbonyl functional group is one of the most important functional groups in organic chemistry. It consists of a carbon atom double-bonded to an...
Chemistry Aldol Condensation
15104The Aldol condensation is a chemical reaction in which two carbonyl compounds react to form a β-hydroxyaldehyde or β-hydroxyketone, also known as a...
Chemistry Alkenes
15106Alkenes are a class of hydrocarbons that contain at least one carbon-carbon double bond. They are unsaturated hydrocarbons, meaning that they have ...
Chemistry Alkynes
15107Alkynes are a class of hydrocarbons that contain at least one carbon-carbon triple bond. They are unsaturated hydrocarbons, meaning that they have ...
Chemistry Aluminium Hydroxide
15108Aluminium hydroxide, also known as hydrated alumina, is a chemical compound with the formula Al(OH)3. It is a white, gelatinous solid that is insoluble in water and amphoteric in nature.
Chemistry Aluminum
15109Aluminum is a lightweight, silvery-white metal that is the most abundant metal in the Earth's crust. It is highly malleable and ductile, making it ...
Chemistry Amines
15110Amines are organic compounds that contain a nitrogen atom bonded to at least one alkyl or aryl group. They are classified as primary, secondary, or...
Chemistry Amino Acid Structure
15111Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. They are the basic units of protein and are essent...
Chemistry Ammonium Chloride
15112Ammonium chloride, also known as sal ammoniac, is a white, crystalline solid with the chemical formula NH4Cl. It is a common nitrogen fertilizer and has various industrial applications.
Chemistry Ammonium Nitrate
15113Ammonium nitrate is a white, crystalline solid with the chemical formula NH₄NO₃. It is highly soluble in water and has a slightly sweet taste. Ammo...
Chemistry Application Of VSEPR
15114The Valence Shell Electron Pair Repulsion (VSEPR) theory is a model used to predict the three-dimensional arrangement of atoms in a molecule. It is...
Chemistry Argon
15115Argon is a chemical element with the symbol Ar and atomic number 18. It is a colorless, odorless, and tasteless gas that is the third most abundant...
Chemistry Aromaticity
15116Aromaticity is a chemical property that describes the stability and special characteristics of certain cyclic compounds. Aromatic compounds are cha...
Chemistry Arrhenius Equation
15117The Arrhenius equation is a mathematical equation that describes the relationship between the rate of a chemical reaction and the temperature at wh...
Chemistry Aryl Halides
15118Aryl halides are organic compounds that contain a halogen atom (fluorine, chlorine, bromine, or iodine) bonded to an aromatic ring. The nomenclatur...
Chemistry Ascorbic Acid
15119Ascorbic acid, also known as vitamin C, is a water-soluble vitamin that is essential for human health. It is found in many fruits and vegetables, a...
Chemistry Aspartic Acid
15120Aspartic acid is an amino acid that is found in many proteins. It is a non-essential amino acid, meaning that the body can produce it on its own. H...
Chemistry Barium Sulfate
15125Barium sulfate is a white, odorless, tasteless, inorganic compound with the chemical formula BaSO4. It is commonly known as blanc fixe and has various medical and industrial applications.
Chemistry Benzene Hexachloride
15126Benzene hexachloride (BHC), also known as hexachlorocyclohexane (HCH), is a colorless, crystalline solid with a musty odor. It is a chlorinated hyd...
Chemistry Benzene Reactions
15127Benzene is a highly stable aromatic hydrocarbon with the chemical formula C6H6. It is a colorless, flammable liquid with a sweet, pungent odor and undergoes various electrophilic aromatic substitution reactions.
Chemistry Benzoic Acid
15128Benzoic acid is a colorless, crystalline organic compound with the chemical formula C6H5COOH. It is the simplest aromatic carboxylic acid and has various industrial applications.
Chemistry Benzyl Alcohol
15129Benzyl alcohol is an aromatic alcohol with the chemical formula C6H5CH2OH. It is a colorless liquid with a mild, sweet odor and has various industrial applications.
Chemistry Boron
15132Boron is a chemical element with the symbol B and atomic number 5. It is a metalloid in the boron group. Boron is a hard, brittle, crystalline soli...
Chemistry Boyles Law
15133Boyle's Law, also known as the Boyle-Mariotte Law, describes the inversely proportional relationship between the pressure and volume of a gas when ...
Chemistry Bravais Lattice
15134A Bravais lattice is a regular arrangement of points in three-dimensional space. It is named after the French physicist Auguste Bravais, who first ...
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Markovnikov’s Rule
Markovnikov’s rule is an empirical observation in organic chemistry that states that when an unsymmetrical alkene reacts with an electrophile, the electrophile adds to the carbon-carbon double bond in a way that results in the more substituted carbon atom becoming bonded to the electrophile.
This rule can be explained by considering the stability of the carbocation intermediates that are formed during the reaction. The more substituted carbon atom is more stable because it is better able to distribute the positive charge.
Markovnikov’s rule is a useful tool for predicting the products of electrophilic addition reactions of alkenes. It is also used to explain the regioselectivity of many other organic reactions.
For example, in the reaction of propene with hydrogen bromide, Markovnikov’s rule predicts that the hydrogen atom will add to the more substituted carbon atom, resulting in the formation of 2-bromopropane.
This is in contrast to the product that would be formed if the hydrogen atom added to the less substituted carbon atom, which would be 1-bromopropane.
What is Markovnikov’s Rule?
Markovnikov’s Rule
Markovnikov’s rule is an empirical observation in organic chemistry that states that when an unsymmetrical alkene reacts with an electrophile, the electrophile adds to the carbon atom of the double bond that has the most hydrogen atoms. This rule is also known as the “principle of least substitution” or the “Markovnikov orientation.”
Examples
The following are some examples of Markovnikov’s rule in action:
- When ethene reacts with hydrogen bromide, the hydrogen atom adds to the carbon atom that has the most hydrogen atoms, resulting in the formation of ethyl bromide.
- When propene reacts with hydrogen bromide, the hydrogen atom adds to the carbon atom that has the most hydrogen atoms, resulting in the formation of isopropyl bromide.
- When 2-methylpropene reacts with hydrogen bromide, the hydrogen atom adds to the carbon atom that has the most hydrogen atoms, resulting in the formation of tert-butyl bromide.
Exceptions to Markovnikov’s Rule
There are a few exceptions to Markovnikov’s rule. One exception is when the alkene is substituted with a strong electron-withdrawing group, such as a carbonyl group or a nitro group. In these cases, the electrophile adds to the carbon atom that is bonded to the electron-withdrawing group.
Another exception to Markovnikov’s rule is when the reaction is carried out in the presence of a Lewis acid catalyst. In these cases, the electrophile adds to the carbon atom that is bonded to the Lewis acid.
Applications of Markovnikov’s Rule
Markovnikov’s rule is a useful tool for predicting the products of electrophilic addition reactions of alkenes. This rule can be used to design synthetic routes to specific organic compounds. For example, Markovnikov’s rule can be used to predict the product of the reaction of ethene with hydrogen bromide to form ethyl bromide.
Conclusion
Markovnikov’s rule is a fundamental principle of organic chemistry that helps to predict the products of electrophilic addition reactions of alkenes. This rule is not always followed, but it is a good starting point for understanding these reactions.
What is the Mechanism Behind Markovnikov’s Rule?
Markovnikov’s rule is an empirical observation in organic chemistry that states that in the addition of a hydrogen halide (HX) to an unsymmetrical alkene, the hydrogen atom adds to the carbon atom that already has the most hydrogen atoms, while the halide atom adds to the carbon atom that has the fewest hydrogen atoms.
This rule can be explained by considering the stability of the carbocation intermediates that are formed during the reaction. When a hydrogen halide adds to an alkene, a carbocation intermediate is formed. The more substituted the carbocation, the more stable it is. This is because the alkyl groups donate electrons to the carbocation, which helps to stabilize the positive charge.
In the case of the addition of a hydrogen halide to an unsymmetrical alkene, the carbocation that is formed when the hydrogen atom adds to the carbon atom that already has the most hydrogen atoms is more stable than the carbocation that is formed when the hydrogen atom adds to the carbon atom that has the fewest hydrogen atoms. This is because the carbon atom that already has the most hydrogen atoms is more electron-rich, and therefore it can donate more electrons to the carbocation.
As a result, the reaction proceeds via the more stable carbocation intermediate, and the hydrogen atom adds to the carbon atom that already has the most hydrogen atoms.
Here are some examples of Markovnikov’s rule:
- When hydrogen bromide (HBr) is added to propene, the major product is 2-bromopropane. This is because the carbocation that is formed when the hydrogen atom adds to the carbon atom that already has the most hydrogen atoms is more stable than the carbocation that is formed when the hydrogen atom adds to the carbon atom that has the fewest hydrogen atoms.
- When hydrogen iodide (HI) is added to 2-methylpropene, the major product is 2-iodo-2-methylpropane. This is because the carbocation that is formed when the hydrogen atom adds to the carbon atom that already has the most hydrogen atoms is more stable than the carbocation that is formed when the hydrogen atom adds to the carbon atom that has the fewest hydrogen atoms.
Markovnikov’s rule is a useful tool for predicting the products of addition reactions of hydrogen halides to alkenes. However, it is important to note that there are some exceptions to the rule. For example, when hydrogen bromide is added to 1-butene, the major product is 1-bromobutane. This is because the carbocation that is formed when the hydrogen atom adds to the carbon atom that already has the most hydrogen atoms is not as stable as the carbocation that is formed when the hydrogen atom adds to the carbon atom that has the fewest hydrogen atoms. This is due to the fact that the methyl group is a better electron donor than the hydrogen atom.
Examples of Markovnikov and Anti-Marknovnikov Addition Reactions
Markovnikov’s Rule
Markovnikov’s rule states that in the addition of a hydrogen halide (HX) to an unsymmetrical alkene, the hydrogen atom adds to the carbon atom that is bonded to the fewer number of hydrogen atoms. This is because the more substituted carbon atom is more stable than the less substituted carbon atom.
For example, when hydrogen bromide (HBr) is added to propene, the hydrogen atom adds to the carbon atom that is bonded to the methyl group, forming 2-bromopropane. This is because the tertiary carbon atom (the carbon atom that is bonded to three other carbon atoms) is more stable than the secondary carbon atom (the carbon atom that is bonded to two other carbon atoms).
Anti-Markovnikov’s Rule
Anti-Markovnikov’s rule is the opposite of Markovnikov’s rule. It states that in the addition of a hydrogen halide (HX) to an unsymmetrical alkene, the hydrogen atom adds to the carbon atom that is bonded to the greater number of hydrogen atoms. This is because the more substituted carbon atom is more stable than the less substituted carbon atom.
For example, when hydrogen bromide (HBr) is added to propene in the presence of a peroxide, the hydrogen atom adds to the carbon atom that is bonded to the two hydrogen atoms, forming 1-bromopropane. This is because the tertiary carbon atom (the carbon atom that is bonded to three other carbon atoms) is more stable than the secondary carbon atom (the carbon atom that is bonded to two other carbon atoms).
Examples
The following are some examples of Markovnikov and anti-Markovnikov addition reactions:
- Markovnikov addition:
- Hydrogen bromide (HBr) adds to propene to form 2-bromopropane.
- Hydrogen chloride (HCl) adds to 2-methylpropene to form 2-chloro-2-methylpropane.
- Hydrogen iodide (HI) adds to 1-butene to form 2-iodobutane.
- Anti-Markovnikov addition:
- Hydrogen bromide (HBr) adds to propene in the presence of a peroxide to form 1-bromopropane.
- Hydrogen chloride (HCl) adds to 2-methylpropene in the presence of a peroxide to form 1-chloro-2-methylpropane.
- Hydrogen iodide (HI) adds to 1-butene in the presence of a peroxide to form 1-iodobutane.
Applications
Markovnikov’s rule is used to predict the products of addition reactions of hydrogen halides to alkenes. This information is important in the synthesis of organic compounds. For example, Markovnikov’s rule can be used to predict the product of the reaction of hydrogen bromide with propene. This information can then be used to synthesize 2-bromopropane, which is a useful solvent.
Anti-Markovnikov’s rule is also used to predict the products of addition reactions of hydrogen halides to alkenes. This information is important in the synthesis of organic compounds. For example, anti-Markovnikov’s rule can be used to predict the product of the reaction of hydrogen bromide with propene in the presence of a peroxide. This information can then be used to synthesize 1-bromopropane, which is a useful alkylating agent.
Anti-Markovnikov Addition Video Lesson
The Anti-Markovnikov Addition reaction is a chemical reaction in which the addition of a hydrogen halide (HX) to an unsymmetrical alkene results in the formation of the more substituted alkyl halide. This is in contrast to the Markovnikov addition reaction, which results in the formation of the less substituted alkyl halide.
The Anti-Markovnikov addition reaction is a result of the stability of the carbocation intermediate that is formed during the reaction. The more substituted carbocation is more stable than the less substituted carbocation, and so it is more likely to form.
The following is an example of an Anti-Markovnikov addition reaction:
CH3CH=CH2 + HBr → CH3CHBrCH3
In this reaction, the hydrogen bromide adds to the double bond in the alkene to form a carbocation intermediate. The carbocation intermediate is then attacked by the bromide ion to form the alkyl halide.
The Anti-Markovnikov addition reaction is a useful reaction for the synthesis of alkyl halides. It can be used to synthesize a variety of alkyl halides, including primary, secondary, and tertiary alkyl halides.
Here are some additional examples of Anti-Markovnikov addition reactions:
CH3CH=CHCH3 + HCl → CH3CHClCH2CH3
(CH3)2C=CH2 + HI → (CH3)2CHI
CH3CH=CH2 + H2O → CH3CH(OH)CH3
The Anti-Markovnikov addition reaction is a versatile reaction that can be used to synthesize a variety of alkyl halides. It is a useful reaction for organic chemists.
Frequently Asked Questions – FAQs
What is the reasoning behind Markovnikov’s Rule?
Markovnikov’s rule is an empirical observation in organic chemistry that states that in the addition of a protic acid HX to an unsymmetrical alkene, the hydrogen atom of the acid adds to the carbon atom of the double bond that already has the most hydrogen atoms, while the halide X adds to the carbon atom with the fewest hydrogen atoms.
This rule can be explained by considering the stability of the carbocation intermediates that are formed during the reaction. When a protic acid adds to an alkene, it first forms a carbocation intermediate. The stability of a carbocation is determined by the number of alkyl groups attached to the positively charged carbon atom. The more alkyl groups that are attached, the more stable the carbocation.
In the case of an unsymmetrical alkene, the carbon atom that already has the most hydrogen atoms is also the carbon atom that is more substituted by alkyl groups. This means that the carbocation intermediate that is formed when the hydrogen atom of the acid adds to this carbon atom is more stable than the carbocation intermediate that is formed when the hydrogen atom of the acid adds to the other carbon atom.
As a result, the reaction proceeds preferentially through the more stable carbocation intermediate, and the hydrogen atom of the acid adds to the carbon atom of the double bond that already has the most hydrogen atoms.
Here are some examples of Markovnikov’s rule:
- When hydrogen bromide (HBr) is added to propene, the major product is 2-bromopropane. This is because the carbocation intermediate that is formed when the hydrogen atom of HBr adds to the carbon atom that already has two hydrogen atoms is more stable than the carbocation intermediate that is formed when the hydrogen atom of HBr adds to the other carbon atom.
- When water (H2O) is added to 2-methylpropene, the major product is 2-methyl-2-propanol. This is because the carbocation intermediate that is formed when the hydrogen atom of H2O adds to the carbon atom that already has two hydrogen atoms is more stable than the carbocation intermediate that is formed when the hydrogen atom of H2O adds to the other carbon atom.
Markovnikov’s rule is a useful tool for predicting the products of addition reactions of protic acids to alkenes. However, it is important to note that this rule is not always followed. There are some exceptions to Markovnikov’s rule, such as the addition of hydrogen bromide to 1-butene, which forms 1-bromobutane as the major product.
Does the following reaction obey Markovnikov’s Rule?
Markovnikov’s Rule states that in the addition of a protic acid HX to an unsymmetrical alkene, the hydrogen atom of the acid adds to the carbon atom of the double bond that has the greater number of hydrogen atoms, while the halogen atom adds to the carbon atom with the fewer hydrogen atoms.
In other words, Markovnikov’s Rule predicts that the more substituted carbon atom of an alkene will be the one that becomes bonded to the hydrogen atom of the acid.
Examples:
-
When HCl is added to propene, the hydrogen atom of the acid adds to the carbon atom that has two hydrogen atoms, while the chlorine atom adds to the carbon atom with one hydrogen atom. The product of this reaction is 2-chloropropane.
-
When HBr is added to 2-methylpropene, the hydrogen atom of the acid adds to the carbon atom that has three hydrogen atoms, while the bromine atom adds to the carbon atom with one hydrogen atom. The product of this reaction is 2-bromo-2-methylpropane.
Exceptions to Markovnikov’s Rule:
There are a few exceptions to Markovnikov’s Rule. One exception is when the alkene is substituted with a strong electron-withdrawing group, such as a carbonyl group or a nitro group. In these cases, the hydrogen atom of the acid adds to the carbon atom that is bonded to the electron-withdrawing group.
Another exception to Markovnikov’s Rule is when the reaction is carried out in the presence of a strong acid, such as sulfuric acid or hydrogen bromide. In these cases, the reaction may follow a different pathway, known as the carbocation pathway. The carbocation pathway involves the formation of a carbocation intermediate, which is then attacked by the nucleophile (in this case, the halide ion).
Applications of Markovnikov’s Rule:
Markovnikov’s Rule is a useful tool for predicting the products of addition reactions of protic acids to alkenes. This information can be used to design synthetic routes to specific organic compounds.
For example, if you wanted to synthesize 2-chloropropane, you could start with propene and add HCl. According to Markovnikov’s Rule, the hydrogen atom of the acid will add to the carbon atom that has two hydrogen atoms, while the chlorine atom will add to the carbon atom with one hydrogen atom. The product of this reaction will be 2-chloropropane.
If the following reaction obeys Markovnikov’s Rule, what would be the Major Product?
Markovnikov’s Rule states that in the addition of a protic acid HX to an unsymmetrical alkene, the hydrogen atom of the acid adds to the carbon atom of the double bond that has the most hydrogen atoms, while the halogen atom adds to the carbon atom with the fewest hydrogen atoms.
In other words, Markovnikov’s Rule predicts that the more substituted carbon atom of an alkene will be the one that bonds to the hydrogen atom of the acid.
Example:
When hydrogen bromide (HBr) is added to propene, the major product is 2-bromopropane. This is because the more substituted carbon atom of propene (the one with two hydrogen atoms) bonds to the hydrogen atom of HBr, while the bromine atom bonds to the less substituted carbon atom (the one with one hydrogen atom).
The reaction can be represented as follows:
CH3CH=CH2 + HBr → CH3CHBrCH3
The minor product of this reaction is 1-bromopropane, which is formed when the hydrogen atom of HBr bonds to the less substituted carbon atom of propene.
Another example:
When water (H2O) is added to 2-methylpropene, the major product is 2-methyl-2-propanol. This is because the more substituted carbon atom of 2-methylpropene (the one with two methyl groups) bonds to the hydrogen atom of H2O, while the oxygen atom bonds to the less substituted carbon atom (the one with one hydrogen atom).
The reaction can be represented as follows:
(CH3)2C=CH2 + H2O → (CH3)2C(OH)CH3
The minor product of this reaction is 1-methyl-2-propanol, which is formed when the hydrogen atom of H2O bonds to the less substituted carbon atom of 2-methylpropene.
Exceptions to Markovnikov’s Rule:
There are a few exceptions to Markovnikov’s Rule. One exception is when the alkene is very hindered. In this case, the hydrogen atom of the acid may add to the less substituted carbon atom in order to avoid steric hindrance.
Another exception is when the reaction is catalyzed by a strong acid. In this case, the reaction may follow a different mechanism that does not obey Markovnikov’s Rule.
What does Markovnikov’s rule predict?
Markovnikov’s rule is an empirical observation in organic chemistry that states that in the addition of a protic acid HX to an unsymmetrical alkene, the hydrogen atom of the acid adds to the carbon atom of the double bond that already has the most hydrogen atoms, while the halide atom adds to the carbon atom with the fewest hydrogen atoms.
In other words, Markovnikov’s rule predicts that the more substituted carbon atom of an alkene will become the major product of an electrophilic addition reaction.
This rule can be explained by considering the stability of the carbocation intermediates that are formed during the reaction. The more substituted carbon atom is more stable because it is better able to disperse the positive charge of the carbocation.
For example, in the addition of hydrogen bromide to propene, the following two carbocation intermediates can be formed:
CH3-CH-CH2+ (primary carbocation) CH3-CH2-CH2+ (secondary carbocation)
The secondary carbocation is more stable than the primary carbocation because the positive charge is dispersed over two carbon atoms instead of one. Therefore, the major product of the reaction will be 2-bromopropane, which is formed by the addition of the hydrogen atom to the more substituted carbon atom.
Markovnikov’s rule is a useful tool for predicting the products of electrophilic addition reactions of alkenes. However, it is important to note that this rule is not always followed. There are some exceptions to Markovnikov’s rule, such as the addition of hydrogen bromide to 1-butene, which forms 1-bromobutane as the major product.
Which reactions do not obey Markovnikov’s rule?
Reactions that do not obey Markovnikov’s rule
Markovnikov’s rule states that in the addition of a hydrogen halide to an unsymmetrical alkene, the hydrogen atom adds to the carbon atom that is bonded to the fewer number of hydrogen atoms. This rule is generally followed, but there are some exceptions.
1. Addition of hydrogen bromide to 1-butene
In the addition of hydrogen bromide to 1-butene, the hydrogen atom adds to the carbon atom that is bonded to the greater number of hydrogen atoms. This is opposite to what is predicted by Markovnikov’s rule.
The reason for this exception is that the hydrogen bromide molecule is polar. The hydrogen atom has a partial positive charge, and the bromine atom has a partial negative charge. The partial positive charge on the hydrogen atom is attracted to the partial negative charge on the carbon atom that is bonded to the greater number of hydrogen atoms. This attraction outweighs the steric hindrance caused by the greater number of hydrogen atoms on that carbon atom.
2. Addition of water to 2-methylpropene
In the addition of water to 2-methylpropene, the oxygen atom adds to the carbon atom that is bonded to the greater number of hydrogen atoms. This is also opposite to what is predicted by Markovnikov’s rule.
The reason for this exception is that the water molecule is polar. The oxygen atom has a partial negative charge, and the hydrogen atoms have partial positive charges. The partial negative charge on the oxygen atom is attracted to the partial positive charge on the carbon atom that is bonded to the greater number of hydrogen atoms. This attraction outweighs the steric hindrance caused by the greater number of hydrogen atoms on that carbon atom.
3. Addition of hydrogen cyanide to styrene
In the addition of hydrogen cyanide to styrene, the hydrogen atom adds to the carbon atom that is bonded to the phenyl group. This is opposite to what is predicted by Markovnikov’s rule.
The reason for this exception is that the phenyl group is a strong electron-withdrawing group. This means that it pulls electrons away from the carbon atom that it is bonded to. This makes the carbon atom more positive, and it is therefore more attractive to the partial negative charge on the hydrogen atom of the hydrogen cyanide molecule.
Conclusion
Markovnikov’s rule is a general rule, but there are some exceptions. These exceptions occur when the reaction conditions are such that the steric hindrance or the polarity of the reactants outweighs the electronic effects that favor the formation of the more substituted alkene.
What is markovnikov’s rule?
Markovnikov’s rule is an empirical observation in organic chemistry that states that when an unsymmetrical alkene reacts with an electrophile, the electrophile adds to the carbon-carbon double bond in such a way that the more substituted carbon atom becomes bonded to the electrophile. This rule is often used to predict the regioselectivity of electrophilic addition reactions of alkenes.
For example, when hydrogen bromide (HBr) reacts with propene (CH3CH=CH2), the major product is 2-bromopropane (CH3CHBrCH3), in which the bromine atom has added to the more substituted carbon atom of the double bond. This is in accordance with Markovnikov’s rule, as the more substituted carbon atom is the one that is bonded to the more electronegative atom (bromine) in the product.
Another example of Markovnikov’s rule is the reaction of water with propene. In this reaction, the major product is isopropyl alcohol (CH3CHOHCH3), in which the oxygen atom has added to the more substituted carbon atom of the double bond. This is again in accordance with Markovnikov’s rule, as the more substituted carbon atom is the one that is bonded to the more electronegative atom (oxygen) in the product.
Markovnikov’s rule is a useful tool for predicting the regioselectivity of electrophilic addition reactions of alkenes. However, it is important to note that this rule is not always followed. There are some exceptions to Markovnikov’s rule, such as the addition of hydrogen cyanide (HCN) to alkenes, which follows the opposite regioselectivity.
Despite these exceptions, Markovnikov’s rule is a valuable tool for understanding the regioselectivity of electrophilic addition reactions of alkenes. It is a simple rule that can be easily applied to a wide variety of reactions.
Name a reaction that follows markovnikov’s rule?
Markovnikov’s rule states that in the addition of a protic acid HX to an unsymmetrical alkene, the hydrogen atom of the acid adds to the carbon atom of the double bond that has the most hydrogen atoms, while the halogen atom adds to the carbon atom with the fewest hydrogen atoms.
This rule can be explained by considering the stability of the carbocation intermediates that are formed during the reaction. The more substituted carbocation is more stable, and therefore more likely to form.
For example, in the addition of hydrogen bromide to propene, the following two carbocation intermediates can be formed:
- 1-Bromopropane: This carbocation is formed by the addition of the hydrogen atom of HBr to the carbon atom of the double bond that has two hydrogen atoms.
- 2-Bromopropane: This carbocation is formed by the addition of the hydrogen atom of HBr to the carbon atom of the double bond that has one hydrogen atom.
The 2-bromopropane carbocation is more stable than the 1-bromopropane carbocation because it is more substituted. This is because the methyl group (CH3) is a more electron-donating group than the hydrogen atom. The electron-donating group helps to stabilize the positive charge on the carbon atom.
As a result of the greater stability of the 2-bromopropane carbocation, the major product of the reaction is 2-bromopropane.
Other examples of reactions that follow Markovnikov’s rule include:
- The addition of water to alkenes
- The addition of hydrogen cyanide to alkenes
- The addition of sulfuric acid to alkenes
Markovnikov’s rule is a useful tool for predicting the products of reactions involving the addition of protic acids to alkenes.
Why does Markovnikov’s rule work?
Markovnikov’s rule states that in the addition of a hydrogen halide (HX) to an unsymmetrical alkene, the hydrogen atom adds to the carbon atom that already has the most hydrogen atoms, while the halide atom adds to the carbon atom that has the fewest hydrogen atoms.
This can be explained by considering the stability of the carbocation intermediates that are formed during the reaction. When a hydrogen halide adds to an alkene, a carbocation intermediate is formed. The stability of a carbocation is determined by the number of alkyl groups that are attached to the positively charged carbon atom. The more alkyl groups that are attached, the more stable the carbocation.
In the case of an unsymmetrical alkene, there are two possible carbocation intermediates that can be formed. The more stable carbocation is the one that is formed by the addition of the hydrogen atom to the carbon atom that already has the most hydrogen atoms. This is because the more alkyl groups that are attached to the positively charged carbon atom, the more stable the carbocation.
The following is an example of Markovnikov’s rule in action. When hydrogen bromide (HBr) is added to propene, the major product is 2-bromopropane. This is because the more stable carbocation intermediate is formed by the addition of the hydrogen atom to the carbon atom that already has two hydrogen atoms.
Markovnikov’s rule is a useful tool for predicting the products of addition reactions of hydrogen halides to alkenes. However, it is important to note that there are some exceptions to the rule. For example, Markovnikov’s rule does not apply to the addition of hydrogen iodide (HI) to alkenes. In this case, the opposite of Markovnikov’s rule is observed, and the hydrogen atom adds to the carbon atom that has the fewest hydrogen atoms.
What is the peroxide effect?
The peroxide effect refers to the phenomenon where the rate of a chemical reaction increases upon the addition of a small amount of an inhibitor. This effect is commonly observed in free radical chain reactions, where the inhibitor acts as a free radical scavenger, reacting with and removing free radicals from the reaction mixture.
Mechanism of the Peroxide Effect:
In a free radical chain reaction, the reaction proceeds through a series of steps involving the initiation, propagation, and termination of free radical chains. The inhibitor, typically a compound containing a double bond or a heteroatom with a lone pair of electrons, reacts with free radicals, forming stable products and effectively reducing the concentration of free radicals in the system.
Examples of the Peroxide Effect:
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Polymerization Reactions: In the free radical polymerization of vinyl monomers, the addition of a small amount of an inhibitor, such as oxygen or a hindered phenol, can significantly increase the rate of polymerization. The inhibitor reacts with free radicals, reducing their concentration and leading to a longer lifetime for the propagating polymer chains. This results in an increased rate of chain growth and higher molecular weight polymers.
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Autoxidation Reactions: The autoxidation of hydrocarbons, such as the oxidation of vegetable oils, involves a free radical chain mechanism. The addition of antioxidants, which are compounds that can scavenge free radicals, can inhibit the autoxidation process and extend the shelf life of the oils.
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Combustion Reactions: In combustion reactions, the addition of small amounts of certain inhibitors, such as halogenated hydrocarbons, can enhance the rate of combustion. These inhibitors react with free radicals, promoting the formation of more reactive species that accelerate the reaction.
Significance of the Peroxide Effect:
The peroxide effect has practical implications in various fields, including polymer chemistry, food preservation, and combustion technology. By understanding and controlling the peroxide effect, it is possible to optimize the performance and efficiency of chemical processes and improve the stability and quality of products.
Name a compound that does not follow Markovnikov’s rule?
Anti-Markovnikov’s Rule
Markovnikov’s rule states that in the addition of a hydrogen halide (HX) to an unsymmetrical alkene, the hydrogen atom adds to the carbon atom that is bonded to the most hydrogen atoms, while the halide atom adds to the carbon atom that is bonded to the fewest hydrogen atoms.
However, there are some exceptions to Markovnikov’s rule. One example is the addition of hydrogen bromide (HBr) to 1-butene. In this reaction, the hydrogen atom adds to the carbon atom that is bonded to the fewest hydrogen atoms, while the bromine atom adds to the carbon atom that is bonded to the most hydrogen atoms. This is known as the anti-Markovnikov addition.
The anti-Markovnikov addition is thought to occur via a free radical mechanism. In this mechanism, the hydrogen bromide molecule dissociates into a hydrogen atom and a bromine atom. The hydrogen atom then adds to the carbon atom that is bonded to the most hydrogen atoms, while the bromine atom adds to the carbon atom that is bonded to the fewest hydrogen atoms.
The anti-Markovnikov addition is also observed in the addition of other hydrogen halides to unsymmetrical alkenes. However, the extent of the anti-Markovnikov addition varies depending on the hydrogen halide. For example, the anti-Markovnikov addition is more pronounced in the addition of hydrogen iodide (HI) than in the addition of hydrogen chloride (HCl).
The anti-Markovnikov addition is a useful reaction for the synthesis of certain organic compounds. For example, the anti-Markovnikov addition of hydrogen bromide to 1-butene can be used to synthesize 2-bromobutane.
Examples of Compounds that do not follow Markovnikov’s Rule
- 1-Butene When 1-butene reacts with hydrogen bromide, the major product is 2-bromobutane, which is the anti-Markovnikov product. This is because the hydrogen atom adds to the carbon atom that is bonded to the fewest hydrogen atoms, while the bromine atom adds to the carbon atom that is bonded to the most hydrogen atoms.
- 2-Methyl-2-butene When 2-methyl-2-butene reacts with hydrogen bromide, the major product is 2-bromo-2-methylbutane, which is the Markovnikov product. This is because the hydrogen atom adds to the carbon atom that is bonded to the most hydrogen atoms, while the bromine atom adds to the carbon atom that is bonded to the fewest hydrogen atoms.
- Cyclohexene When cyclohexene reacts with hydrogen bromide, the major product is cyclohexyl bromide, which is the Markovnikov product. This is because the hydrogen atom adds to the carbon atom that is bonded to the most hydrogen atoms, while the bromine atom adds to the carbon atom that is bonded to the fewest hydrogen atoms.
Conclusion
Markovnikov’s rule is a useful tool for predicting the products of addition reactions of hydrogen halides to alkenes. However, there are some exceptions to this rule, such as the anti-Markovnikov addition. The anti-Markovnikov addition is a useful reaction for the synthesis of certain organic compounds.