NEET Solved Paper 2017 Question 31
Question: Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?
Options:
A) Recombination of chromosome arms will occur
B) Chromosomes will not condense
C) Chromosomes will be fragmented
D) Chromosomes will not segregate
Show Answer
Answer:
Correct Answer: D
Solution:
- The APC is crucial for the progression of mitosis, particularly for the transition from metaphase to anaphase. It facilitates the degradation of securin, which in turn allows separase to cleave cohesin, the protein complex that holds sister chromatids together. If the APC is defective, securin is not degraded, separase remains inactive, and the sister chromatids cannot be separated and pulled to opposite poles of the cell. This results in a failure of chromosome segregation.
BETA
