NEET Solved Paper 2019 Question 23
Question: Under which of the following conditions will there be no change in the reading frame of following mRNA? [NEET 5-5-2019]
5’ AACAGCGGUGCUAUU 3'
Options:
A) Insertion of A and G at 4th and 5th positions respectively
B) Deletion of GGU from 7th, 8th and 9th positions
C) Insertion of G at 5th positions
D) Deletion of G from 5th positions
Show Answer
Answer:
Correct Answer: B
Solution:
- A) Insertion of A and G at 4th and 5th positions respectively: Original sequence: 5’ AACAGCGGUGCUAUU 3' After insertion: 5’ AACAAGCGGUGCUAUU 3' This insertion adds two nucleotides, which will shift the reading frame.
B) Deletion of GGU from 7th, 8th, and 9th positions: Original sequence: 5’ AACAGCGGUGCUAUU 3' After deletion: 5’ AACAGCUAUU 3' This deletion removes three nucleotides, which will not shift the reading frame because it removes a complete codon.
C) Insertion of G at 5th position: Original sequence: 5’ AACAGCGGUGCUAUU 3' After insertion: 5’ AACAGGCGGUGCUAUU 3' This insertion adds one nucleotide, which will shift the reading frame.
D) Deletion of G from 5th position: Original sequence: 5’ AACAGCGGUGCUAUU 3' After deletion: 5’ AACACGGUGCUAUU 3' This deletion removes one nucleotide, which will shift the reading frame.
BETA
